发明名称 |
COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B |
摘要 |
The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non- mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein. |
申请公布号 |
WO2014052555(A1) |
申请公布日期 |
2014.04.03 |
申请号 |
WO2013US61868 |
申请日期 |
2013.09.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE;XUE, DING;GENG, XIN |
发明人 |
XUE, DING;GENG, XIN |
分类号 |
A61K48/00;A61K31/713;A61P31/20;C12N5/10;C12N15/11;C12N15/51;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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