发明名称 |
PROCESS FOR PREPARING LEVOSIMENDAN AND INTERMEDIATES FOR USE IN THE PROCESS |
摘要 |
<p>In an embodiment, the present invention provides a process for preparing (−)-6-(4-aminophenyl)-5-methylpyridazin-3-(2H)-one, which process comprises: a) reacting racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone of formula II with a chiral tartaric acid derivative to obtain a diastereomeric salt of (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone and the chiral tartaric acid derivative; and b) reacting the diastereomeric salt with a base to obtain (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone. The (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone may be used to prepare levosimendan.</p> |
申请公布号 |
EP2454241(B1) |
申请公布日期 |
2014.04.02 |
申请号 |
EP20100732405 |
申请日期 |
2010.07.12 |
申请人 |
CIPLA LIMITED |
发明人 |
RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO;PHULL, MANJINDER, SINGH;SAWANT, ASHWINI, AMOL |
分类号 |
C07D237/04 |
主分类号 |
C07D237/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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