发明名称 |
New anti-invasive compounds |
摘要 |
<p>The present invention relates to a compound of formula (I):
wherein
A and A' independently represent a phenylene group or a pyridylene group; R 2 is a hydrogen atom or a (C 1 -C 4 )alkyl group; R 3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R 4 is a carbonyl group or a sulfonyl group; and R 5 is a - NH-(CH 2 ) a -NR 6 R 7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R 6 and R 7 representing independently a (C 1 -C 4 )alkyl group, or R 6 and R 7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.
The invention further relates to pharmaceutical compositions containing a compound of formula (I) or any one of its pharmaceutically acceptable salt and a preparation process for obtaining the same. Said compounds (I) are useful for treating cancer.</p> |
申请公布号 |
EP2712862(A1) |
申请公布日期 |
2014.04.02 |
申请号 |
EP20120186684 |
申请日期 |
2012.09.28 |
申请人 |
SPLICOS;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT CURIE;UNIVERSITE MONTPELLIER II |
发明人 |
ROUX, PIERRE;MAHUTEAU, FLORENCE;NAJMAN, ROMAIN;GADEA, GILLES;TAZI, JAMAL;SCHERRER, DIDIER;BROCK, CARSTEN;CAHUZAC, NATHALIE, M. |
分类号 |
C07D213/75;A61K31/44;A61P35/00;C07D239/42;C07D401/12 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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