发明名称 |
METHOD FOR LABELING OF COMPOUNDS |
摘要 |
The present invention relates to site-specific labeling of antibodies or fragments thereof with one or more reporter group(s) in a way that does not affect antigen binding. The method for labeling antibodies and/or fragments thereof, comprises the following steps a) providing an IgG binding protein, which comprises α-helix structures, with a photoactivatable group and at least one label; b) forming a mixture of said IgG binding protein and the antibodies and/or fragments to be labeled; and c) UV illuminating said mixture for site-specific labeling of said antibodies and/or fragments thereof. The IgG binding protein is preferably the Z domain of Protein A. |
申请公布号 |
EP2614371(A4) |
申请公布日期 |
2014.04.02 |
申请号 |
EP20110823846 |
申请日期 |
2011.09.05 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
HOBER, SOPHIA;ERIKSSON KARLSTROEM, AMELIE;KONRAD, ANNA |
分类号 |
G01N33/532 |
主分类号 |
G01N33/532 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|