| 发明名称 |
Compositions and methods for inhibiting sphingosine kinase |
| 摘要 |
Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells. |
| 申请公布号 |
US8686046(B2) |
申请公布日期 |
2014.04.01 |
| 申请号 |
US20100896881 |
申请日期 |
2010.10.02 |
| 申请人 |
LYNCH KEVIN R.;MACDONALD TIMOTHY L.;KHAREL YUGESH;MATHEWS THOMAS P.;WAMHOFF BRIAN R.;UNIVERSITY OF VIRGINIA PATENT FOUNDATION |
发明人 |
LYNCH KEVIN R.;MACDONALD TIMOTHY L.;KHAREL YUGESH;MATHEWS THOMAS P.;WAMHOFF BRIAN R. |
| 分类号 |
A61K31/175;C07C257/14 |
主分类号 |
A61K31/175 |
| 代理机构 |
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