发明名称 |
COMBINATIONS OF 7-T-BUTOXYIMINOMETHYLCAMPTOTHECIN WITH ONE OR MORE CHEMOTHERAPEUTIC AGENTS FOR TREATING CANCERS |
摘要 |
<p>A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with a camptothecin derivative and one or more chemotherapeutic agents selected from a microtubule active agent; an alkylating agent; an anti-neoplastic anti-metabolite; a platin compound; a topoisomerase II inhibitor; a VEGF inhibitor; a tyrosine kinase inhibitor; an EGFR kinase inhibitor; an mTOR kinase inhibitor; an insulin-like growth factor I inhibitor; a Raf kinase inhibitor; a monoclonal antibody; a proteasome inhibitor; a HDAC inhibitor; and ionizing radiation.</p> |
申请公布号 |
CA2589521(C) |
申请公布日期 |
2014.04.01 |
申请号 |
CA20052589521 |
申请日期 |
2005.12.13 |
申请人 |
NOVARTIS AG;SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
ZAKNOEN, SARA;WOO, MARGARET MA;VERSACE, RICHARD WILLIAM;PISANO, CLAUDIO;VESCI, LOREDANA |
分类号 |
A61K31/4745;A61K31/282;A61K31/337;A61K31/427;A61K31/53;A61K31/555;A61K33/24;A61K39/395;A61P35/00 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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