发明名称 |
Heterologous protection against Pasteurella multocida provided by P. multocida fur cells and the outer-membrane protein extracts thereof |
摘要 |
The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida . Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants. |
申请公布号 |
US8685413(B2) |
申请公布日期 |
2014.04.01 |
申请号 |
US20090865287 |
申请日期 |
2009.01.29 |
申请人 |
BARBE GARCIA JORGE;BADIOLA SAIZ IGNACIO;CASAS MONTSERRAT LLAGOSTERA;GARRIDO OCANA MARIA ELENA;BOSCH GALLEGO MONTSERRAT;PEREZ DE ROZAS RUIZ DE GAUNA ANA MARIA;UNIVERSITAT AUTONOMA DE BARCELONA |
发明人 |
BARBE GARCIA JORGE;BADIOLA SAIZ IGNACIO;CASAS MONTSERRAT LLAGOSTERA;GARRIDO OCANA MARIA ELENA;BOSCH GALLEGO MONTSERRAT;PEREZ DE ROZAS RUIZ DE GAUNA ANA MARIA |
分类号 |
A61K39/02;A61K39/00;A61K39/102;A61K39/38;C07K1/00;C07K14/00;C07K17/00;C12N1/20 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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