发明名称 |
Sequence-specific inhibition of small RNA function |
摘要 |
The present invention relates to the discovery of a method for inhibiting RNA silencing in a target sequence-specific manner. RNA silencing requires a set of conserved cellular factors to suppress expression of gene-encoded polypeptide. The invention provides compositions for sequence-specific inactivation of the RISC component of the RNA silencing pathway, and methods of use thereof. The RISC inactivators of the present invention enable a variety of methods for identifying and characterizing miRNAs and siRNAs, RISC-associated factors, and agents capable of modulating RNA silencing. Therapeutic methods and compositions incorporating RISC inactivators and therapeutic agents identified through use of RISC inactivators are also featured. |
申请公布号 |
US8685946(B2) |
申请公布日期 |
2014.04.01 |
申请号 |
US20040998364 |
申请日期 |
2004.11.26 |
申请人 |
HUTVAGNER GYOERGY;ZAMORE PHILLIP D.;UNIVERSIY OF MASSACHUSETTS |
发明人 |
HUTVAGNER GYOERGY;ZAMORE PHILLIP D. |
分类号 |
A01N43/04;C12N15/11;C12N15/85;C12Q;C12Q1/68 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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