PYRIMIDINYL SULFONAMIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4

摘要

DISCLOSED ARE COMPOUNDS, WHICH BIND VLA-4. CERTAIN OF THESE COMPOUNDS ALSO INHIBIT LEUKOCYTE ADHESION AND IN PARTICULAR, LEUKOCYTE ADHESION MEDIATED BY VLA-4. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES IN A HUMAN OR ANIMAL SUBJECT SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS DEMENTIA, DIABETES INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS AND MYOCARDIAL ISCHEMIA. THE COMPOUNDS CAN ALSO BE, ADMINISTERED FOR THE TREATMENT OF INFLAMMATORY BRAIN DISEASES SUCH AS MULTIPLE SCLEROSIS.