MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS

摘要

COMPOUNDS OF THE FORMULA (I): AND N-OXIDES, SALTS, AND STEREOISOMERS THEREOF WHEREIN A IS OR¹, NHS(=O)pR²; WHEREIN; R¹ IS HYDROGEN, C?-C?ALKYL, C?-C?ALKYLENECARBOCYCLYL, C?-C?ALKYLENE-HETEROCYCLYL; R² IS C?-C?ALKYL, C?-C?ALKYLENECARBOCYCLYL, C?-C?ALKYLENEHETEROCYCLYL; P IS INDEPENDENTLY 1 OR 2; N IS 3, 4, 5 OR 6; ---- DENOTES AN OPTIONAL DOUBLE BOND; L IS N OR CRz; Rz IS H OR FORMS A DOUBLE BOND WITH THE ASTERISKED CARBON; Rq IS H OR WHEN L IS CRz, Rq CAN ALSO BE C?-C?ALKYL; Rr IS QUINAZOLINYL, OPTIONALLY SUBSTITUTED WITH ONE TWO OR THREE SUBSTITUENTS EACH INDEPENDENTLY SELECTED FROM C?-C?ALKYL, C?-C?ALKOXY, HYDROXYL, HALO, HALOC?-C?ALKYL, AMINO, MONO- OR DIALKYLAMINO, MONO- OR DIALKYLAMINOCARBONYL, C?-C?ALKYL-CARBONYLAMINO, C?-C?ALKYLENECARBOCYCLYL AND C?-C?ALKYLENEHETEROCYCLYL; R? IS HYDROGEN, C?-C?ALKYL, C?-C?ALKOXYC?-C?ALKYL OR C?-C?CYCLOALKYL; R? IS HYDROGEN, C?-C?ALKYL, C?-C?ALKOXY, C?-C?ALKYLENECARBOCYCLYL, C?-C?ALKYLENEHETEROCYCLYL, HYDROXY, BROMO, CHLORO OR FLUORO HAVE UTILITY IN THE TREATMENT OR PROPHYLAXIS OF FLAVIVIRAL INFECTIONS SUCH AS HCV.