| 摘要 |
<p>597611 Disclosed is an isolated antibody or an antigen binding portion thereof, that specifically binds to human Notch-1, wherein the antibody or antigen binding portion thereof binds to at least a first epitope and a second epitope, wherein the first epitope resides within the Lin-A domain of human Notch-1 set forth as amino acid residues 3 to 44 of SEQ ID NO: 22, wherein the first epitope is a major epitope comprising 1 to 4 amino acid residues selected from 1463V, 1465S, 1466L and 1467Q; and, the second epitope resides within the HD-C domain of human Notch-1 set forth as amino acid residues 267 to 288 of SEQ ID NO: 22, wherein the second epitope is a major epitope comprising 1 to 5 amino acid residues selected from 1705G, 1706A, 1707L, 1709S and 1710L. Further disclosed is an isolated antibody or an antigen binding portion thereof that specifically binds to human Notch-1, comprising: (i) a heavy chain variable region CDR1 comprising SEQ ID NO: 18 (NYWME), (ii) a heavy chain variable region CDR2 comprising SEQ ID NO: 19 (EILPGRGRTNYNENFKG), (iii) a heavy chain variable region CDR3 comprising SEQ ID NO: 20 (FHSSAYYYTMPY), (iv) a light chain variable region CDR1 comprising SEQ ID NO: 12 (RSSTGAVTTSNYAN), (v) a light chain variable region CDR2 comprising SEQ ID NO: 13 (GTNNRAP), and (vi) a light chain variable region CDR3 comprising SEQ ID NO: 14 (ALWYSNHWV).</p> |
