| 摘要 |
600017 The present disclosure provides a 5-hydroxypyrimidine-4-carboxamide derivative compound represented by formula (1), which enhances the production of erythropoietin and wherein, R1: formula (lB), Compounds of the disclosure include: ({ [2-({ 1-[4’-(acetoxymethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(1-hydroxyethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(2-hydroxypropyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(2-hydroxy-1,1-dimethylethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [2-({ 1-[4’-(dimethylcarbamoyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [2-({ 1-[2’-fluoro-4’-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(hydroxymethyl)-3’-isopropylbiphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, And [({ 2-[(1-{ 5-[3-chloro-4-(hydroxymethyl)phenyl]pyridin-2-yl} piperidin-4-yl)methyl]-5-hydroxy-6-methylpyrimidin-4-yl} carbonyl)amino]acetic acid The diseases which these compounds may be used to treat include: Anemia, nephrogenic anemia, anemia of prematurity, anemia incidental to chronic diseases, anemia incidental to cancer chemotherapy, cancerous anemia, inflammation-associated anemia, or anemia incidental to congestive heart failure. |
