| 摘要 |
597738 Disclosed herein is a process for preparing (R)- and (S)-N-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comprising: i) contacting 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-methoxybenzene-1,2-diamine with a sulfonyl chloride of formula (II-a) or formula (II-b); and ii) contacting a protected diol of formula (I-a) or formula (I-b) with an acid, a base or a nucleophile, or exposing the compound of formula (I-a) or formula (I-b) to UV light. Additionally disclosed are intermediate compounds Additionally disclosed are intermediate compounds (R)- and (S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonyl chloride, and (R)- and (S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride. |
