DOLASTATIN 10 DERIVATIVES, PROCESS FOR PREPARING THE SAME AND ANTI-CANCER AGENTS COMPRISING THE SAME

摘要

The present invention provides a dolastatin-10 derivative having excellent anticancer activity, a method for manufacturing the same, and an anticancer drug composition comprising the same as an active ingredient. The dolastatin-10 derivative of the present invention is a novel synthetic compound which can be used for treating a tumor, slowing growth of tumors, and preventing an increase in number of tumors. For example, the dolastatin-10 derivative is effective to inhibit or prevent the growth of tumor in permalignant and malignant cells.