| 摘要 |
NZ 597306 Disclosed is a polypeptide selected from: a polypeptide consisting of an amino acid sequence having at least 95% identity to SEQ ID NOs: 5, 6, or 7; a polypeptide consisting of an Angpt13 variant amino acid sequence substantially identical to SEQ ID NOs: 5, 6, or 7; or a polypeptide consisting of an amino acid sequence of SEQ ID NOs: 5, 6, or 7, wherein said polypeptide comprises an amino acid sequence having at least 95% identity to SEQ ID NO: 5, the polypeptide has chondrogenic activity and the sequences are as defined in the complete specification. Also disclosed is a method of ameliorating or preventing arthritis or joint injury in a nonhuman mammal, the method comprising, administering to a joint of the mammal a composition comprising an effective amount of a polypeptide consisting of an ANGPTL3 C-terminal fibrinogen domain peptide having chondrogenic activity comprising an amino acid sequence substantially identical and having at least 95% identity to SEQ ID NO: 5, as defined in the complete specification. |
