| 摘要 |
This disclosure relates to a process of preparing paclitaxel with high yield by semi-synthesis of paclitaxel from paclitaxel intermediate in one pot. According to the preparation process of the present invention, total steps may be progressed in one-pot reaction without separating intermediate by using 10-deacetylpaclitaxel as starting material, the process is very economical because less amount of reagents may be used, paclitaxel may be obtained with high yield amounting to 80~95% even when the process is applied for mass production by including crystallization and purification processes, thus obtaining paclitaxel more easily and efficiently, and the process is very advantageous when applied for industrial mass production of paclitaxel. |
