Substituted phenylureas and phenylamides as vanilloid receptor ligands

摘要

595759 Disclosed herein are substituted phenylureas and phenylamides of formula (I), processes for the preparation thereof, pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions. These compounds are useful for the treatment of diseases or disorders mediated by vanilloid receptors 1 (CR1/TRPV1 receptors). In specific embodiments the compound is N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-{ methylsulphonamido)phenyl)propanamide or 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-{ 3-fluoro-4-methylsulphonyl) phenyl)urea