NOVEL PRODRUGS FOR SELECTIVE ANTICANCER THERAPY

摘要

The present invention provides a compound having the structure: (Formula (I)) wherein X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbonα; Z is CH3 or CF3; R1 is -H, -NR2R3, -NH-C (=0) -R4, -NH-C (=0) -0R4, -CH2-C (=0) -NR5R6, -OR7, -CO2R7, C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, aryl, or heteroaryl, wherein R2, R3, R4, R5, R6 and R7 are each, independently, -H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, an amino acid or an oligopeptide; wherein an amine of the amino acid or oligopeptide is substituted or unsubstituted; and n is an integer from 0 to 6; or a diastereomer, enantiomer or pharmaceutically acceptable salt of the compound.