POLYPEPTIDE BASED BLOCK COPOLYMER AND THE PROCESS FOR THE PREPARATION THEREOF, AND THE POLYMER MICELLES USING THE SAME

摘要

The present invention relates to a polypeptide based block copolymer having biodegradability by peptidase, a method for preparing the same, and polymeric micelles using the same. The block copolymer according to the present invention is a block copolymer of: a polyethylene glycol based compound of which the solubility to water varies depending on pH but which does not form micelles through self-assembling; and a polyglutamic acid based compound which is formed by an aminolysis reaction of glutamic acid and tertiary amine of which one end of an alkyl group is substituted with NH_2 or an aminolysis reaction of triamine and glutamic acid. The block copolymer of the present invention retains pH sensitivity as well as biodegradability by in vivo peptidase, and thus its degrading rate associated with the drug release period can be controlled. Therefore, a target-oriented drug delivery system dependent on the pH change and a drug delivery system capable of controlling a degrading rate can be provided.