发明名称 |
Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester HCl |
摘要 |
The invention relates to a process for the preparation of trans 4-amino-cyclohexil ethyl acetate HCl wherein d) hydrogenating 4-nitrophenyl acetic acid in a protic solvent at a temperature between 40-500C in the presence of Pd/C under 0.1-0.6 bar overpressure, and e) further hydrogenating the 4-aminophenyl acetic acid obtained in situ in step a) at a temperature between 50-60 0C under 1-4 bar overpressures, then f) heating to reflux the 4-aminocyclohexil acetic acid obtained in step b) for 1-3 hours in hydrochloric ethanol, and if desired after removing the solvent acetonitrile was added to the residue obtained and distilled off. |
申请公布号 |
AU2009329293(B2) |
申请公布日期 |
2014.03.27 |
申请号 |
AU20090329293 |
申请日期 |
2009.12.17 |
申请人 |
RICHTER GEDEON NYRT. |
发明人 |
MATHE, TIBOR BENCE;HEGEDUS, LASZO;CZIBULA, LASZO;JUHASZ, BALINT;NAGYNE BAGDY, JUDIT;MARKOS, DENES |
分类号 |
C07C227/04;C07C227/16;C07C227/18;C07C229/46 |
主分类号 |
C07C227/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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