IN VITRO PREPARATION METHOD OF ROTAVIRUS DOUBLE-LAYER VIRUS-LIKE PARTICLES

摘要

The present invention relates to an in vitro preparation method of rotavirus double-layer virus-like particles, comprising: purifying a rotavirus VP6 protein in a cracked supernatant, and performing in vitro assembly of double-layer virus-like particles formed by a VP2 protein and the VP6 protein. The proteins and the virus-like particles can be used to prevent or alleviate clinical symptoms caused by infection of the rotavirus.