发明名称 |
Complexation of Metal Ions with Polypeptides |
摘要 |
Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide. |
申请公布号 |
US2014088013(A1) |
申请公布日期 |
2014.03.27 |
申请号 |
US201313789593 |
申请日期 |
2013.03.07 |
申请人 |
DURECT CORPORATION |
发明人 |
ROHLOFF CATHERINE M.;CHEN GUOHUA;DING ZHONGLI;BERRY STEPHEN A.;NARAYANAN LATHA P.;DESJARDIN MICHAEL A. |
分类号 |
A61K47/32;A61K38/27;A61K47/10;A61K47/12;A61K47/14;A61K47/22;A61K47/34;A61K47/44 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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