发明名称 |
PREDICTIVE BIOMARKERS FOR CTLA-4 BLOCKADE THERAPY AND FOR PD-1 BLOCKADE THERAPY |
摘要 |
<p>Biomarkers are described for predicting the efficacy, risk of relapse, risk of an immune related adverse event (irAE), or combination thereof for a CTLA-4 blockade treatment, such as ipilimumab, in a subject with melanoma. Biomarkers are also described for predicting the efficacy and clinical benefit for a PD-1 blockade treatment, such as a PD-1 blocking antibody, in a subject with melanoma.</p> |
申请公布号 |
WO2013169388(A9) |
申请公布日期 |
2014.03.27 |
申请号 |
WO2013US32254 |
申请日期 |
2013.03.15 |
申请人 |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. |
发明人 |
WEBER, JEFFREY, S.;WANG, WENSHI;YU, BIN |
分类号 |
G01N33/68;G01N33/48;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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