发明名称 CHALCONE DERIVATIVES AS NRF2 ACTIVATORS
摘要 Compounds and methods for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.
申请公布号 US2014088052(A1) 申请公布日期 2014.03.27
申请号 US201214000816 申请日期 2012.02.27
申请人 BISWAL SHYAM;THIMMULAPPA RAJESH;KUMAR SARVESH;MALHOTRA SANJAY V.;KUMAR VINEET;JUNG-HYUN KIM;THE JOHNS HOPKINS UNIVERSITY 发明人 BISWAL SHYAM;THIMMULAPPA RAJESH;KUMAR SARVESH;MALHOTRA SANJAY V.;KUMAR VINEET;JUNG-HYUN KIM
分类号 A61K31/121;A61K45/06;C07C49/84 主分类号 A61K31/121
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