发明名称 |
METHODS AND COMPOSITIONS FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS BY RNAA |
摘要 |
The present disclosure provides methods for inducing somatic cells to form induced pluripotent stem (iPS) cells. The method includes introducing a small activating RNA (saRNA) molecule into the somatic cell, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure also provides compositions and kits comprising a saRNA molecule that increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. The present disclosure provides iPS cells comprising at least one exogenous saRNA molecule, where the saRNA molecule increases transcription of a transcription factor that induces the formation of induced pluripotent stem cells. |
申请公布号 |
WO2012027486(A3) |
申请公布日期 |
2014.03.27 |
申请号 |
WO2011US48985 |
申请日期 |
2011.08.24 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;LI, LONG-CHENG |
发明人 |
LI, LONG-CHENG |
分类号 |
C12N5/02;C07H21/04;C12N5/071;C12N15/00 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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