发明名称 |
SUBGROUP B RECOMBINANT HUMAN ADENOVIRUS VECTOR, AND METHODS FOR CONSTRUCTING AND FOR USING THE SAME |
摘要 |
A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP. The method includes substituting a 365 bp fragment including an enhancer and a promoter of an upstream coding sequence of Ad5 E1A for a corresponding region of a serotype Ad11 of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP. A subgroup B recombinant human adenovirus vector Ad11-5EP constructed by the method and the use thereof for treatment of tumors are also provided. |
申请公布号 |
US2014088180(A1) |
申请公布日期 |
2014.03.27 |
申请号 |
US201314093078 |
申请日期 |
2013.11.29 |
申请人 |
BEIJING BIO-TARGETING THERAPEUTICS TECHNOLOGY INC. |
发明人 |
WANG YAOHE;JIANG GUOZHONG;WONG HANSHI;CAO FENGYU;LEMOINE NICK |
分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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地址 |
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