| 摘要 |
The present invention discloses a process for the synthesis and purification of methylcobalamin by using dimethyl sulphate as alkylating agent, either alone or in a Vilsmeier complex, with non-alkylated, mono-alkylated and dialkylated amides, sodium borohydride as reducing agent and without the use of a chelating agent. Purification thereof is carried out using two different methods, namely repulping in water and acetone-water, or resin. |
