发明名称 |
Methods of Predicting The Probability of Modulation of Transcript Levels By RNAI Compounds |
摘要 |
The present invention provides a method for determining the probability that an RNAi compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an RNAi compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model. The present invention provides a method for determining the seed-sequence-dependent signature size of an RNAi compound using the linear regression model. The invention provides a method for identifying genes having seed-sequence-dependent silencing effect by an siRNA using the linear regression model. The invention further provides a method for selecting from a plurality of siRNAs one or more siRNAs with higher silencing efficacy, specificity and diversity in silencing a target gene in an organism. The invention also provides a method for determining the coefficients of the above linear regression model. |
申请公布号 |
US2014088937(A1) |
申请公布日期 |
2014.03.27 |
申请号 |
US201314091459 |
申请日期 |
2013.11.27 |
申请人 |
BROWN DUNCAN;BURCHARD JULJA;BUEHLER EUGEN C.;MERK SHARP & DOHME CORP. |
发明人 |
BROWN DUNCAN;BURCHARD JULJA;BUEHLER EUGEN C. |
分类号 |
G06F19/12;G06F19/18 |
主分类号 |
G06F19/12 |
代理机构 |
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地址 |
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