| 发明名称 |
N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| 摘要 |
The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting RORγactivity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydroquinoline and related compounds are provided. |
| 申请公布号 |
US2014088094(A1) |
申请公布日期 |
2014.03.27 |
| 申请号 |
US201113883419 |
申请日期 |
2011.11.08 |
| 申请人 |
GLICK GARY D.;TOOGOOD PETER L.;ROMERO ARTHUR GLENN;VAN HUIS CHAD A.;AICHER THOMAS DANIEL;KAUB CARL;MATTSON MATTHEW N.;THOMAS WILLIAM DAVID;STTEIN KARIN ANN;KROGH-JESPERSEN ERIK;WANG ZHAN;MERCK SHARP & DOHME CORP.;LYCERA CORPORATION |
发明人 |
GLICK GARY D.;TOOGOOD PETER L.;ROMERO ARTHUR GLENN;VAN HUIS CHAD A.;AICHER THOMAS DANIEL;KAUB CARL;MATTSON MATTHEW N.;THOMAS WILLIAM DAVID;STTEIN KARIN ANN;KROGH-JESPERSEN ERIK;WANG ZHAN |
| 分类号 |
C07D231/56;C07D215/58;C07D265/36;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/06;C07D413/12;C07D417/12 |
主分类号 |
C07D231/56 |
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