发明名称 |
METHOD FOR INHIBITING CELLULAR ACTIVATION BY INSULIN-LIKE GROWTH FACTOR-1. |
摘要 |
A method of inhibiting cellular activation by Insulin-like Growth Factor-1 (IGF-1) in a subject in need thereof (e.g., a subject afflicted with cancer, atherosclerosis, diabetic retinopathy or other disease) comprises administering an antagonist that inhibits the binding of IAP to SHPS-1 to the subject in an amount effective to inhibit cellular activation by IGF-1. Compounds and compositions for carrying out such methods are also described. |
申请公布号 |
MX2014002296(A) |
申请公布日期 |
2014.03.27 |
申请号 |
MX20140002296 |
申请日期 |
2012.08.24 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
CLEMMONS, DAVID R.;MAILE, LAURA A. |
分类号 |
A61K39/395;A61K38/30;A61P29/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|