发明名称 |
MICROCRYSTALLINE CELLULOSE AND CALCIUM PHOSPHATE COMPOSITIONS USEFUL AS PHARMACEUTICAL EXCIPIENTS |
摘要 |
Compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. The recompactibility performance of such compositions is improved through the use of calcium phosphate having a relatively small particle size, e.g., a median particle size of not more than about 20 microns or not more than about 10 microns. |
申请公布号 |
EP2498818(A4) |
申请公布日期 |
2014.03.26 |
申请号 |
EP20100828973 |
申请日期 |
2010.11.02 |
申请人 |
FMC CORPORATION |
发明人 |
THOORENS, GREGORY;LECLERCQ, BRUNO;RUSZKAY, THOMAS |
分类号 |
A61K47/04;A61K9/16;A61K9/20;A61K31/375;A61K47/02;A61K47/30;A61K47/38 |
主分类号 |
A61K47/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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