发明名称 |
METHOD FOR MAKING CUSTOMISED NANOPARTICLES, NANOPARTICLES AND USES THEREOF |
摘要 |
The invention proposes a method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. According to the invention, in a first step a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises at least two repetitive units based on the cyclic monomer. In a second step this macromonomer or a mixture of macromonomers and/or commercial biocompatible monomers is polymerized, e.g. in a starved, miniemulsion or emulsion radical polymerization in water in the presence of a surfactant to the nanoparticle without necessitating additional subsequent steps for the actual production of the nanoparticles. The invention furthermore pertains to correspondingly made nanoparticles and uses thereof. |
申请公布号 |
EP2709601(A1) |
申请公布日期 |
2014.03.26 |
申请号 |
EP20120723106 |
申请日期 |
2012.05.14 |
申请人 |
ETH ZURICH |
发明人 |
MOSCATELLI, DAVIDE;LATTUADA, MARCO;MORBIDELLI, MASSIMO;YU, YINGCHUAN |
分类号 |
A61K9/51 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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