<p>This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.</p>
申请公布号
EP2709997(A1)
申请公布日期
2014.03.26
申请号
EP20120721812
申请日期
2012.05.14
申请人
F.HOFFMANN-LA ROCHE AG
发明人
BILLEDEAU, ROLAND J.;KONDRU, RAMA K.;LOPEZ-TAPIA, FRANCISCO JAVIER;LOU, YAN;OWENS, TIMOTHY D.;QIAN, YIMIN;SO, SUNG-SAU;THAKKAR, KSHITIJ CHHABILBHAI;WANNER, JUTTA;MORALES, OMAR JOSE