发明名称 |
PLATELET STORAGE USING A SIALIDASE INHIBITOR |
摘要 |
The present invention relates to a platelet additive solution (PAS) having an amount of one or more sialidase inhibitors and optionally one or more glycan-modifying agents; and one or more of PAS components that includes a salt, a citrate source, a carbon source, and any combination thereof. The present invention also relates to methods, compositions and kits for increasing the in vivo circulation time of isolated platelets by storing the platelets with one or more sialidase inhibitors. Additionally, the present invention relates to methods and compositions for reducing sialidase activity and inhibiting bacterial proliferation of one or more bacteria in a platelet product preparation from one or more donors. |
申请公布号 |
EP2709446(A2) |
申请公布日期 |
2014.03.26 |
申请号 |
EP20120726520 |
申请日期 |
2012.05.17 |
申请人 |
VELICO MEDICAL, INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
LIU, QIYONG PETER;HOFFMEISTER, KARIN;SACKSTEIN, ROBERT |
分类号 |
A01N1/00 |
主分类号 |
A01N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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