发明名称 METHOD FOR PRODUCING N-SUBSTITUTED-2-AMINO-4-(HYDROXYMETHYLPHOSPHINYL)-2-BUTENOIC ACID
摘要 Provided is a method for producing a compound expressed by the following formula (3): [where R 1 represents a hydrogen atom or C 1-4 alkyl group, and R 2 represents C 1-4 alkyl group, C 1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1): [where R 1 represents the same meaning as defined above], and a compound expressed by the following formula (2): [where R 2 represents the same meaning as defined above], while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene, and a mixing ratio of acetic acid to the other solvent is from 1:3 to 1:5 in volume, wherein the reaction is conducted under heating and refluxing.
申请公布号 ZA201300322(B) 申请公布日期 2014.03.26
申请号 ZA20130000322 申请日期 2013.01.14
申请人 MEIJI SEIKA PHARMA CO., LTD. 发明人 ANDO TAKASHI;MINOWA NOBUTO;MITOMI MASAAKI
分类号 C07F;C07B 主分类号 C07F
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