发明名称 |
Method for modulating inflammatory responses |
摘要 |
The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject. |
申请公布号 |
US8679501(B2) |
申请公布日期 |
2014.03.25 |
申请号 |
US20060090369 |
申请日期 |
2006.11.01 |
申请人 |
NOELLE RANDOLPH J.;LU LI-FAN;AHONEN CORY L.;TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
NOELLE RANDOLPH J.;LU LI-FAN;AHONEN CORY L. |
分类号 |
A61K39/395;A61K39/00;A61K39/38 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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