| 摘要 |
A process of preparation ofα-ketoglutaric acid for mass production of L-arginineα-ketoglutarate 1:1 and 2:1 includes the steps of: reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain Dimethyl 2,2 -dichloroglutarate; reacting the dimethyl 2,2-dichloroglutarate with hydroxide solution to obtain crudeα-ketoglutaric acid aqueous solution; purifying the crudeα-ketoglutaric acid aqueous solution to obtain purifiedα-ketoglutaric acid aqueous solution; and adjusting the concentration of the purifiedα-ketoglutaric acid aqueous solution by adding water. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time. |
