发明名称 |
PROGRAMMABLE DRUG DELIVERY PROFILES OF TUMOR-TARGETED BACTERIA |
摘要 |
The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences. |
申请公布号 |
WO2014043593(A2) |
申请公布日期 |
2014.03.20 |
申请号 |
WO2013US59832 |
申请日期 |
2013.09.13 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BHATIA, SANGEETA N.;DANINO, TAL |
分类号 |
A61K39/02 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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