发明名称 |
METHOD OF PREPARING [123I]IODOOCTYL FENBUFEN AMIDE AND APPLICATION THEREOF |
摘要 |
The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/μmol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis. |
申请公布号 |
US2014079633(A1) |
申请公布日期 |
2014.03.20 |
申请号 |
US201313757018 |
申请日期 |
2013.02.01 |
申请人 |
NATIONAL TSING HUA UNIVERSITY |
发明人 |
YU CHUNG-SHAN;HUANG HO-LIEN;YEH CHUN-NAN;LEE WEI-YUAN;CHANG KANG-WEI;HUANG YING-CHENG;LIN KUN-JU;YANG CHING-SHIUANN;TIEN SHU-FAN;SU WEN-CHIN;CHEN JENN-TZONG;LIN WUU-JYH;FARN SHIOU-SHIOW |
分类号 |
A61K51/04;C07C231/12 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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