METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES

摘要

FIELD: chemistry.SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfect G-quadruplexes (lmGQ) which include one nucleotide substitution in the Gplane in the G-quadruplexes (GQ). Said method includes using an algorithm describing nucleotide sequences in form of a defined set of formulae for further synthesis of selected oligonucleotides.EFFECT: invention enables to use bioinformation analysis to obtain artificial oligonucleotides that are potentially capable of forming a new conformation - imperfect G-quadruplexes.4 dwg, 2 tbl, 2 ex