[4-(5-AMINOMETHYL-2-FLOUROPHENYL)-PYPERIDIN-1-YL]-(7- FLUORO-1-(2-METHOXYETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS MAST CELL TRYPTASE INHIBITOR

摘要

FIELD: chemistry.SUBSTANCE: present invention relates to indole benzylamino compound of formula Iand pharmaceutically acceptable salts thereof. The invention also relates to use of the compound to treat a patient in such a physiological state or susceptible to such a physiological state which needs improvement by inhibiting tryptase and involves administering a therapeutically effective amount of the compound to the patient. The present invention also relates to a pharmaceutical composition containing a pharmaceutically effective amount of the compound of formula I for treating the physiological state by inhibiting tryptase.EFFECT: novel compound which can be used as a tryptase inhibitor is obtained and described.17 cl, 13 ex, 2 tbl