COMPOSITION COMPRISING CYCLOPHILIN A FOR PREVENTING ALOPECIA OR IMPROVING HAIR RESTORATION

摘要

The present invention relates to a composition comprising a cyclophilin A (cyp A) protein, a nucleic acid having a nucleotide sequence coding for the cyp A protein, or a recombinant vector for expressing the cyp A protein for preventing alopecia or improving hair restoration. The composition of the present invention is administered to skin cells in order to suppress the IL-1 expression of skin cells, regulate the activity of ERK and c-jun, and increase the expression of NF-&kgr;B p65, thereby promoting growth and development of hair follicles. Thus, the present invention can be valuable in the use thereof for the preventing and treatment of alopecia-related diseases.