| 摘要 |
A complex having the formula:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ [L 3 MO 3 ] n
wherein L 3 represents a tridentate ligand, M represents a metal selected from Tc and Re, and n is a charge from -2 to +1, provided that L 3 is not di-1H-pyrazol-1-ylacetate, bis(3,5-dimethyl-1H-pyrazol-1-yl)acetate, 1,1,1-methanetriyltris(1H-pyrazole), 1,1,1-methanetriyltris(3,5-dimethyl-1H-pyrazole), 1,4,7-triazacyclononane, 1,4,7-trimethyltriazacyclononane, 1,4,7-trithiacyclononane, hydrotris(1-pyrazolyl)borate or [(· 5 -C 5 H 5 )Co{P(OR) 2 (=O)} 3 ] - , where R is methyl or ethyl;
or a complex having the formula:
[L 3 MO 3 ] n
wherein L 3 represents a tridentate ligand bearing one or more functional groups suitable for facilitating the attachment of a targeting moiety, or bearing one or more linker groups capable of bearing such a functional groups, M represents a metal selected from Tc and Re, and n is a charge from -2 to +1, provide that, when L 3 bears one or more linker groups, none of which bears a functional group suitable for the attachment of a targeting moiety, at least one of the linker groups contains at least three carbon atoms,
pharmaceutical compositions thereof, and dialato derivatives of [L 3 MO 3 ] n and methods for their synthesis. |
