| 发明名称 |
Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease |
| 摘要 |
<p>Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A² amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.</p> |
| 申请公布号 |
EP2527315(B1) |
申请公布日期 |
2014.03.19 |
| 申请号 |
EP20120166370 |
申请日期 |
2003.05.30 |
| 申请人 |
PROTEOTECH INC. |
发明人 |
SNOW ALAN, D.;NGUYEN, BETH, P.;CASTILLO, GERARDO, M.;SANDERS, VIRGINIA, J.;LAKE, THOMAS, P.;LARSEN, LESLEY;LARSEN, DAVID S.;WEAVERS, REX T.;LORIMER, STEPHEN D.;COFFEN, DAVID, L. ( DECEASED ) |
| 分类号 |
C07C49/83;C07D295/08;A61K31/05;A61K31/121;A61K31/137;A61K31/165;A61K31/166;A61K31/167;A61K31/17;A61K31/4375;A61K31/439;A61K31/4418;A61K31/495;A61P3/10;A61P5/00;A61P25/00;A61P25/28;A61P35/00;A61P43/00;C07C37/055;C07C39/15;C07C39/16;C07C39/17;C07C43/23;C07C45/62;C07C45/64;C07C45/65;C07C49/835;C07C67/08;C07C67/14;C07C69/017;C07C69/157;C07C215/48;C07C215/50;C07C233/18;C07C233/25;C07C233/56;C07C235/34;C07C235/38;C07C235/48;C07C235/54;C07C235/56;C07C237/20;C07C237/22;C07C275/34;C07D207/16;C07D213/30;C07D213/84;C07D213/85;C07D217/26;C07D231/06;C07D263/18;C07D295/096;C07D295/18;C07D295/192;C07D333/16;C07D451/06;C07D471/04;C07D487/04;C07D498/08 |
主分类号 |
C07C49/83 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
