Neue Pyridine

摘要

The invention comprises 5-nitrofurfurylidene compounds of the formula wherein R is a substituted or unsubstituted 2-pyridyl or 2-quinolyl group and R1 is hydrogen, C1- 6 alkyl, or substituted or unsubstituted phenyl, acid addition salts and quaternary derivatives of these compounds, and the process for the manufacture of the compounds by reacting 5-nitro-furfural with a compound of the formula R-CH2-R1. The substituents which may be present on the 2-pyridyl, 2-quinolyl and phenyl groups are C1- 6 alkyl, hydroxyl, acyloxy (e.g. alkanoyloxy), C1- 6 alkoxy, trifluoromethyl, nitro and amino groups and halogen atoms. Pharmaceutical preparations having antibacterial action comprise the above compounds of the invention in admixture or conjunction with an organic or inorganic solid or liquid carrier suitable for enteral (e.g. oral), parenteral or local administration. The active compounds may be used in the form of their salts with inorganic or organic acids, including therapeutically active acids such as p-aminobenzoic, salicylic and p-aminosalicylic acids, methionine, tryptophan, lysine or arginine, or in the form of quaternary ammonium derivatives such as the alkyl, alkenyl or aralkyl halides, arylsulphonates or alkylsulphates. The preparations may suitably take the form of tablets, dragees, capsules, creams, ointments, suspensions, solutions and emulsions and may contain, in addition to conventional carriers, preserving, stabilizing, wetting or emulsifying agents, salts for regulating osmotic pressure or buffers.