发明名称 |
Encoded self-assembling chemical libraries (ESACHEL) |
摘要 |
The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue thereof. The oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1') of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In some embodiments, the chemical compound comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) and further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m') of a similar chemical compound comprising a chemical moiety (q). The invention also provides corresponding libraries of chemical compounds as well as methods of biopanning of for target molecules and of identifying such targets. |
申请公布号 |
US8673824(B2) |
申请公布日期 |
2014.03.18 |
申请号 |
US20090613475 |
申请日期 |
2009.11.05 |
申请人 |
NERI DARIO;MELKKO SAMU;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH |
发明人 |
NERI DARIO;MELKKO SAMU |
分类号 |
C40B40/06;C07H21/00;C07H21/04;C12Q1/68;C40B30/04;G01N33/58 |
主分类号 |
C40B40/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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