发明名称 |
Apparatus and methods for performing electrochemical reactions |
摘要 |
The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors underminimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods. |
申请公布号 |
US8673627(B2) |
申请公布日期 |
2014.03.18 |
申请号 |
US20100785716 |
申请日期 |
2010.05.24 |
申请人 |
NOBILE JOHN;ROTH THOMAS;REARICK TODD;SCHULTZ JONATHAN;ROTHBERG JONATHAN;MARRAN DAVID;LIFE TECHNOLOGIES CORPORATION |
发明人 |
NOBILE JOHN;ROTH THOMAS;REARICK TODD;SCHULTZ JONATHAN;ROTHBERG JONATHAN;MARRAN DAVID |
分类号 |
C12M1/34;C12M1/00;C12M3/00;C12Q1/68;G01N27/403 |
主分类号 |
C12M1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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