发明名称 |
MISFOLDED PROTEIN SENSOR METHOD |
摘要 |
A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation. |
申请公布号 |
CA2448981(C) |
申请公布日期 |
2014.03.18 |
申请号 |
CA20022448981 |
申请日期 |
2002.05.30 |
申请人 |
ARETE ASSOCIATES |
发明人 |
ORSER, CINDY;GROSSET, ANNE;DAVIDSON, EUGENE |
分类号 |
C07K14/47;C07K14/00;G01N33/483;G01N33/58;G01N33/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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