发明名称 |
SITE-DIRECTED MONO-SUBSTITUTED PEGYLATED EXENDIN ANALOG AND PREPARATION METHOD THEREFOR |
摘要 |
<p>The invention discloses site-specific mono-PEGylated Exendin analogs in which any amino groups can be mono-PEGylated as well as their preparation method and use. The method of the present invention adopts a more stable protective group Dde (N-±-1-(4,4-dimethyl-2, 6-dioxo-cyclohexylene)) to avoid multi-PEGylated side reactions rendered by unstable protecting groups, achieving mono-PEGylated Exendin analogs at a high recovery with a low reaction molar ratio.</p> |
申请公布号 |
KR20140033023(A) |
申请公布日期 |
2014.03.17 |
申请号 |
KR20137028242 |
申请日期 |
2012.03.05 |
申请人 |
SHANGHAI HUAYI BIO-LAB CO., LTD. |
发明人 |
YUE PENG |
分类号 |
C07K1/06;A61P3/10;C07K14/575 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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