发明名称 |
TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES |
摘要 |
The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion. |
申请公布号 |
US2014073572(A1) |
申请公布日期 |
2014.03.13 |
申请号 |
US201314043317 |
申请日期 |
2013.10.01 |
申请人 |
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT;THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE |
发明人 |
GILKESON GARY;TOMLINSON STEPHEN;HOLERS V. MICHAEL;ROHRER BAERBEL |
分类号 |
C07K14/705;C07K14/47 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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